{"id":22,"date":"2018-07-11T09:27:32","date_gmt":"2018-07-11T08:27:32","guid":{"rendered":"http:\/\/wp.cs.ucl.ac.uk\/evol-genome\/?page_id=22"},"modified":"2026-01-26T17:49:38","modified_gmt":"2026-01-26T17:49:38","slug":"publications","status":"publish","type":"page","link":"https:\/\/wp.cs.ucl.ac.uk\/evol-genome\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<h5><strong>Preprints<\/strong><\/h5>\n<ul>\n<li class=\"p1\"><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2025.05.23.655374v1\" target=\"_blank\" rel=\"noopener\"><strong>Climate associated natural selection in the human mitochondrial genome.<\/strong> <\/a><br \/>\n<span style=\"text-decoration: underline\">Grover-Thomas F<\/span>, van Dorp L, Balloux F, <span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>, Camus F.<br \/>\n<span class=\"s2\">BioRxiv 2025.<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h5><strong>Papers<\/strong><\/h5>\n<ul>\n<li><a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2516263123\" target=\"_blank\" rel=\"noopener\"><strong>Sudan\u2019s complex genetic admixture history drives adaptation to malaria in Sudanese Copts.<\/strong> <\/a><br \/>\nVil\u00e0-Valls L,\u00a0Garcia-Calleja J, Prado-Mart\u00ednez J, Bosch E, \u00a0<span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>, Netea MG, Comas D, \u00a0Hassan HY.<br \/>\n<em>PNAS<\/em>\u00a02026. 123 (3) e2516263123.\u00a0https:\/\/doi.org\/10.1073\/pnas.2516263123<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong><a href=\"https:\/\/www.cell.com\/ajhg\/fulltext\/S0002-9297(25)00315-5\" target=\"_blank\" rel=\"noopener\">Global impact of micronutrients in modern human evolution.<\/a><\/strong><br \/>\n<span style=\"text-decoration: underline\">Rees J,<\/span>\u00a0Castellano S, <span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>.<br \/>\n<em>American Journal Human Genetics<\/em>\u00a02025. 112,1\u201324. 10. https:\/\/doi.org\/1016\/j.ajhg.2025.08.005.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong><a href=\"https:\/\/www.cell.com\/cell\/pdf\/S0092-8674(25)00739-1.pdf\" target=\"_blank\" rel=\"noopener\">Human-specific gene expansions contribute\u00a0to brain evolution.<\/a><\/strong><br \/>\nSoto DC, Uribe-Salazar JM, Kaya, Valdarrago R, Sekar A, Haghani NK, Hino K, La G, Mariano NAF, Ingamells C, Baraban A, Jamal Z, Turner TN, Green ED , Simo S,\u00a0Quon G, <span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>,\u00a0Dennis MY.<br \/>\n<em>Cell<\/em>\u00a02025. 188, 1\u201321.\u00a0https:\/\/doi.org\/10.1016\/j.cell.2025.06.037<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Media article.\u00a0<em>English:\u00a0<\/em><a href=\"https:\/\/theconversation.com\/chimpanzee-genes-have-changed-over-time-to-suit-local-conditions-new-study-250973?utm_medium=Social&amp;utm_source=LinkedIn#Echobox=1742414131\">Chimpanzee genes have changed over time to suit local conditions \u2013 new study.<\/a>\u00a0<em>French<\/em>:\u00a0<a href=\"https:\/\/theconversation.com\/les-genes-des-chimpanzes-ont-evolue-pour-sadapter-aux-conditions-locales-selon-une-nouvelle-etude-253356\">Les g\u00e8nes des chimpanz\u00e9s ont \u00e9volu\u00e9 pour s&#8217;adapter aux conditions locales, selon une nouvelle \u00e9tude.<\/a><br \/>\n<span style=\"text-decoration: underline\">Ostridge H<\/span>, \u00a0<span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>,\u00a0Arandjelovic M.<br \/>\n<em>The Conversation, <\/em>March 2025<em>.<br \/>\n<\/em><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adn7954\" target=\"_blank\" rel=\"noopener\">Local Genetic Adaptation to Habitat in Wild Chimpanzees.<\/a><\/strong>\u00a0Free-access reprint <a href=\"https:\/\/www.science.org\/stoken\/author-tokens\/ST-2354\/full\" target=\"_blank\" rel=\"noopener\">HERE<\/a>.<br \/>\n<span style=\"color: #808080\"><em><span style=\"text-decoration: underline\">Summary translations <\/span>to French, Kiswahili\/Swahili, Italian and Spanish<\/em> <a style=\"color: #808080\" href=\"https:\/\/wp.cs.ucl.ac.uk\/evol-genome\/translations-2\/\" target=\"_blank\" rel=\"noopener\">here<\/a>.<\/span><br \/>\n<span style=\"text-decoration: underline\">Ostridge H<\/span>, Fontsere C, Lizano E, Soto DC, <span style=\"text-decoration: underline\">Schmidt JM<\/span>, <span style=\"text-decoration: underline\">Saxena V<\/span>, Alvarez-Estape M, Barratt CD, Gratton P, Bocksberger G, Lester JD, Dieguez P, \u00a0Agbor A, Angedakin S, Assumang AK, Bailey E, Barubiyo D, Bessone M, Brazzola G, Chancellor R, Cohen H, Coupland C, Danquah E, Deschner T, Dotras L, Dupain J, Ebot Egbe V, Granjon AC, Head J, Hedwig D, \u00a0Hermans V, \u00a0Hernandez-Aguilar RA, Jeffery KJ, Jones S, Junker J, Kadam P, Kaiser M, Kalan AK, Kambere M, Kienast I, Kujirakwinja D, Langergraber KE, Lapuente J, \u00a0Larson B, Laudisoit A, Lee KC, Llana M, Maretti G, Mart\u00edn R, Meier A, Morgan D, Neil E, Nicholl S, Nixon S, Normand E, Orbell C, Ormsby LJ, Orume R, Pacheco L, Preece J, Regnaut S, Robbins MM, Rundus A, Sanz C, Sciaky L, Sommer V, Stewart FA, Tagg N, T\u00e9donzong LR, van Schijndel J, Vendras E, \u00a0Wessling EG, Willie J, Wittig RM, Yuh YG, Yurkiw K, Vigilant L, Piel A, Boesch C, K\u00fchl HS, Dennis MY, Marques-Bonet T, Arandjelovic A, <span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>.<br \/>\n<em>Science<\/em> 2025. 10 Jan 2025;\u00a0387(6730). doi:\u00a010.1126\/science.adn7954<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><a href=\"https:\/\/www.cell.com\/action\/showPdf?pii=S0960-9822%2824%2901284-3\" target=\"_blank\" rel=\"noopener\"><strong>Deep Genetic Substructure within Bonobos.<\/strong><\/a><br \/>\n<em><span style=\"color: #808080\"><span style=\"text-decoration: underline\">Summary translations<\/span> to French, Spanish, German, Korean and Spanish <a style=\"color: #808080\" href=\"https:\/\/wp.cs.ucl.ac.uk\/evol-genome\/translations-2\/\">here<\/a>.<\/span><\/em><br \/>\n<span style=\"text-decoration: underline\">Han S<\/span>*, <span style=\"text-decoration: underline\">de Filippo C<\/span>*, <span style=\"text-decoration: underline\">Parra G<\/span>, <span style=\"text-decoration: underline\">Meneu JR<\/span>, Laurent R, Frandsen P, Hvilsom C, Gronau I, Marques-Bonet T, Kuhlwilm M, <span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>.<br \/>\n<em>Current Biology <\/em>2024. 34:1-8. doi: 10.1016\/j.cub.2024.09.043<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><a href=\"https:\/\/academic.oup.com\/gbe\/article\/16\/3\/evae041\/7623291\" target=\"_blank\" rel=\"noopener\"><strong>Ancient Loss of Catalytic Selenocysteine Spurred Convergent Adaptation in a Mammalian Oxidoreductase.<\/strong><\/a><br \/>\n<span style=\"text-decoration: underline\">Rees J<\/span>, Sarangi G, Cheng Q, Floor M, <span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>, Oliva Miguel B, Vill\u00e0-Freixa J, Arn\u00e9r ESJ, Castellano S.<br \/>\n<em>Genome Biol Evol.<\/em> 2024. Mar 2;16(3):evae041. doi: 10.1093\/gbe\/evae041.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong><a href=\"https:\/\/www.nature.com\/articles\/s41559-023-02145-2\" target=\"_blank\" rel=\"noopener\">Ghost admixture in eastern gorillas.<\/a><\/strong><br \/>\nPawar H, Cuadros S, de Manuel M, van der Valk T, Lobon I, Alvarez-Estape M, Haber M, Dolgova O, Han S, Ayub Q, Bautista R, Kelley JL, Cornejo OE, Lao O, <span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>, Guschanski K, Ssebide B, Cranfield M, Tyler-Smith K, Xue Y, Prado-Martinez J, Marques-Bonet T, Kuhlwilm M.<br \/>\n<i>Nature Ecology and Evolution 2023. 7:<span class=\"u-visually-hidden\">\u00a0<\/span>1503\u20131514<\/i>.\u00a0https:\/\/doi.org\/10.1101\/2022.12.19.521012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong><a href=\"https:\/\/academic.oup.com\/gbe\/article\/15\/3\/evad032\/7055906\" target=\"_blank\" rel=\"noopener\">Inferring balancing selection from genome-scale data<\/a>.<\/strong><br \/>\n<span style=\"text-decoration: underline\">Bitarello B<\/span>, <span style=\"text-decoration: underline\">Brandt DYC<\/span>, Meyer D and <span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>.<br \/>\n<em>Genome Biol Evol<\/em>. 2023. 15(3):evad032. doi: 10.1093\/gbe\/evad032.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><a href=\"https:\/\/journals.plos.org\/plosgenetics\/article\/comments?id=10.1371\/journal.pgen.1010337\" target=\"_blank\" rel=\"noopener\"><strong>Genetic adaptations to SIV across chimpanzee populations<\/strong><\/a><strong>.<\/strong><br \/>\n<span style=\"text-decoration: underline\">Pawar H<\/span>, <span style=\"text-decoration: underline\">Ostridge HJ<\/span>, <span style=\"text-decoration: underline\">Schmidt JM<\/span>, <span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>.<br \/>\n<em>PLoS Genet.<\/em>\u00a02022. 18(8): e1010337.\u00a0https:\/\/doi.org\/10.1371\/journal.pgen.1010337<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong><a href=\"https:\/\/www.cell.com\/cell-genomics\/fulltext\/S2666-979X(22)00062-3\" target=\"_blank\" rel=\"noopener\">Population dynamics and genetic connectivity in recent chimpanzee history.<\/a><\/strong><br \/>\nFontserre C, &#8230; <em>many authors<\/em> &#8230; ,\u00a0<span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>,\u00a0Hughes D,\u00a0K\u00fchl H,\u00a0Lizano E,\u00a0Arandjelovic M,\u00a0Marques-Bonet T.<br \/>\n<em>Cell Genomics<\/em> 2022 June 8; 6:100133.\u00a0https:\/\/doi.org\/10.1016\/j.xgen.2022.100133<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.abo0498\" target=\"_blank\" rel=\"noopener\"><strong>Inferring human evolutionary history.\u00a0<\/strong><\/a>Free-access reprint <a href=\"https:\/\/www.science.org\/stoken\/author-tokens\/ST-357\/full\" target=\"_blank\" rel=\"noopener\">HERE<\/a>.<br \/>\n<span style=\"text-decoration: underline\">Rees J<\/span> and <span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>.<br \/>\n<em>Science<\/em> 2022 Feb 25;375(6583):817-818. doi: 10.1126\/science.abo0498.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0168952520300706\/pdfft?md5=899814c8c9091742fbc83232de86df31&amp;pid=1-s2.0-S0168952520300706-main.pdf\" target=\"_blank\" rel=\"noopener\">The Genomics of Human Local Adaptation<\/a>.<\/strong><br \/>\n<span style=\"text-decoration: underline\">Rees JS<\/span>, Castellano S, <span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>.<br \/>\n<em>Trends Genet.<\/em> 2020 Jun;36(6):415-428. doi: 10.1016\/j.tig.2020.03.006.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong><a href=\"https:\/\/www.mdpi.com\/2073-4425\/11\/3\/276\" target=\"_blank\" rel=\"noopener\">Identification of Structural Variation in Chimpanzees Using Optical Mapping and Nanopore Sequencing<\/a>.<\/strong><br \/>\nSoto DC, Shew C, Mastoras M, <span style=\"text-decoration: underline\">Schmidt JM<\/span>, Sahasrabudhe R, Kaya G, <span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>, Dennis MY.<br \/>\n<em>Genes (Basel).<\/em> 2020 Mar 4;11(3):276. doi: 10.3390\/genes11030276.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong><a href=\"https:\/\/journals.plos.org\/plosgenetics\/article\/file?id=10.1371\/journal.pgen.1008485&amp;type=printable\" target=\"_blank\" rel=\"noopener\">The impact of genetic adaptation on chimpanzee subspecies differentiation.<\/a><\/strong><br \/>\n<span style=\"text-decoration: underline\">Schmidt JM<\/span>, de Manuel M, Marques-Bonet T, Castellano S, <span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>.<br \/>\n<em>PLoS Genet.<\/em> 2019 Nov 25;15(11):e1008485. doi: 10.1371\/journal.pgen.1008485.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong><a href=\"https:\/\/www.nature.com\/articles\/s41467-019-12173-x.pdf\" target=\"_blank\" rel=\"noopener\">Evolutionary and functional impact of common polymorphic inversions in the human genome.<\/a><\/strong><br \/>\nGiner-Delgado C, Villatoro S, Lerga-Jaso J, Gay\u00e0-Vidal M, Oliva M, Castellano D, Pantano L, <span style=\"text-decoration: underline\">Bitarello BD<\/span>, Izquierdo D, Noguera I, Olalde I, Delprat A, Blancher A, Lalueza-Fox C, Esko T, O&#8217;Reilly PF, <span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>, Ferretti L, Puig M, C\u00e1ceres M.<br \/>\n<em>Nat Commun<\/em>. 2019 Sep 17;10(1):4222. doi: 10.1038\/s41467-019-12173-x.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong><a href=\"https:\/\/academic.oup.com\/gbe\/article-pdf\/11\/4\/1178\/28523912\/evz047.pdf\" target=\"_blank\" rel=\"noopener\">Genetic Variation in Pan Species Is Shaped by Demographic History and Harbors Lineage-Specific Functions.\u00a0<\/a><br \/>\n<\/strong>Han S, <span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>, Marques-Bonet T, Kuhlwilm M.<br \/>\n<em>Genome Biol Evol.<\/em> 2019 Apr 1;11(4):1178-1191. doi: 10.1093\/gbe\/evz047.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6347564\/pdf\/evy271.pdf\" target=\"_blank\" rel=\"noopener\">Immune Gene Diversity in Archaic and Present-day Humans.<\/a><\/strong><br \/>\n<span style=\"text-decoration: underline\">Reher D<\/span>, <span style=\"text-decoration: underline\">Key FM<\/span>, <span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>, Kelso J.<br \/>\n<em>Genome Biol Evol.<\/em> 2019 Jan 1;11(1):232-241. doi: 10.1093\/gbe\/evy271.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong><a href=\"https:\/\/journals.plos.org\/plosgenetics\/article\/file?id=10.1371\/journal.pgen.1007298&amp;type=printable\" target=\"_blank\" rel=\"noopener\">Human local adaptation of the TRPM8 cold receptor along a latitudinal cline.<\/a><\/strong><br \/>\n<span style=\"text-decoration: underline\">Key FM<\/span>, <span style=\"text-decoration: underline\">Abdul-Aziz MA<\/span>, Mundry R, Peter BM, Sekar A, D&#8217;Amato M, Dennis MY, <span style=\"text-decoration: underline\">Schmidt JM<\/span>, <span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>.<br \/>\n<em>PLoS Genet.<\/em> 2018 May 3;14(5):e1007298. doi: 10.1371\/journal.pgen.1007298.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5952967\/pdf\/evy054.pdf\" target=\"_blank\" rel=\"noopener\">Signatures of Long-Term Balancing Selection in Human Genomes.<\/a><\/strong><br \/>\n<span style=\"text-decoration: underline\">Bitarello BD<\/span>, <span style=\"text-decoration: underline\">de Filippo C<\/span>, <span style=\"text-decoration: underline\">Teixeira JC<\/span>, <span style=\"text-decoration: underline\">Schmidt JM<\/span>, <span style=\"text-decoration: underline\">Kleinert P<\/span>, Meyer D, <span style=\"text-decoration: underline\">Andr\u00e9s AM<\/span>.<br \/>\n<em>Genome Biol Evol.<\/em> 2018 Mar 1;10(3):939-955. doi: 10.1093\/gbe\/evy054.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>A high-coverage Neandertal genome from Vindija Cave in Croatia.<\/strong><br \/>\nPr\u00fcfer K, de Filippo C, Grote S, Mafessoni F, <em>28 authors<\/em>, Andr\u00e9s AM, Kelso J, Meyer M, P\u00e4\u00e4bo S.<br \/>\n<em>Science<\/em>, 358:655-658 (2017).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Natural selection in the great apes.<\/strong><br \/>\nCagan A*, Theunert C*, Laayouni H*, Santpere G*, Pybus M, Casals F, Pr\u00fcfer K, Navarro A, Marques-Bonet T, Bertranpetit J<sup>#<\/sup>, Andr\u00e9s AM<sup>#<\/sup>.<br \/>\n<em>Molecular Biology and Evolution<\/em>, 33:268-283 (2016)<em>.<\/em><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Chimpanzee genomic diversity reveals ancient admixture with bonobos.<\/strong><br \/>\nde Manuel M*, Kuhlwilm M*, Frandsen P*, <em>25 authors<\/em>, Andr\u00e9s AM, Siegismund HR, Scally A, Excoffier L, Tyler-Smith C, Castellano S, Xue Y, Hvilsom C<sup>#<\/sup>, Marques-Bonet T<sup>#<\/sup>.<br \/>\n<em>Science<\/em>, 354:477-481 (2016).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Human adaptation and population differentiation in the light of ancient genomes.<\/strong><br \/>\nKey FM, Fu Q, Romaine F, Lachmann M, Andr\u00e9s AM.<br \/>\n<em>Nature Communications<\/em> 7:10775-86 (2016).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Recent selective pressure changes in human genes previously affected by balancing selection.<\/strong><br \/>\nde Filippo C, Key FM, Ghirotto S, Benazzo A, Meneu JR, Weihmann A, NISC Comparative Sequence Program, Parra G, Green ED, Andr\u00e9s AM.<br \/>\n<em>Molecular Biology and Evolution, <\/em>33: 1435-1447 (2016).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Ancient gene flow from early modern humans into Eastern Neanderthals.<\/strong><br \/>\nKuhlwilm M*, Gronau I*, Hubisz JM, de Filippo C, Prado J, Kircher M, Fu Q, Lalueza-Fox C, de la Rasilla M, Rosas A, Rudan P, Brajkovic D, Kucan Z, Gusic I, Marques-Bonet T, Andr\u00e9s AM, Viola B, Meyer M, P\u00e4\u00e4bo S, Siepel A and Castellano S.<br \/>\n<em>Nature<\/em> 530: 429\u2013433 (2016).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Adaptive variation in human toll-like receptors is contributed by Neanderthal- and Denisova-like introgressed haplotypes.<\/strong><br \/>\nDanemann M, Andr\u00e9s AM, Kelso J.<br \/>\n<em>The American Journal of Human Genetics<\/em> 98: 22\u201333 (2016).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Demographic History of the Genus Pan Inferred from Whole Mitochondrial Genome Reconstructions.<\/strong><br \/>\nLobon I, Tucci S, de Manuel M, Ghirotto S, Benazzo A, Prado-Martinez J, Lorente-Galdos B, Nam K, Dabad M, Hernandez-Rodriguez J, Comas D, Navarro A, Schierup MH, Andr\u00e9s AM, Barbujani G, Hvilsom C, Marques-Bonet T.<br \/>\n<em>Genome Biology and Evolution<\/em> 8:2020-2030 (2016).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Long-term balancing selection in LAD1 maintains a missense trans-species <strong>polymorphism in humans, chimpanzees and bonobos.<\/strong><br \/>\nTeixeira J*, Filippo C*, Weihmann A, Meneu JR, Racimo F, Dannemann M, Nickel B, Fischer A, Halbwax M, Andre C, Atencia R, Meyer M, Parra G, P\u00e4\u00e4bo S and Andr\u00e9s AM.<br \/>\n<em>Molecular Biology and Evolution<\/em>, 32: 1186-1196 (2015).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Genetic adaptation to levels of dietary selenium in recent human history.<\/strong><br \/>\nWhite L, Romagn\u00e9 F, Erlebach E, Weihmann A, Parra G, Andr\u00e9s AM, Castellano S.<br \/>\n<em>Molecular Biology and Evolution <\/em>32: 1507-1518 (2015).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Selection on a variant\u00a0associated with improved viral clearance induced local, adaptive pseudogenization of interferon lambda 4 (<em>IFNL4<\/em>).<\/strong><br \/>\nKey FM, Peter B, Dennis M, Huerta-S\u00e1nchez E, Tang W, Prokunina-Olsson L, Nielsen R, Andr\u00e9s AM.<br \/>\n<em>PLoS Genetics<\/em> 10:e1004681 (2014).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Patterns of coding variation in the complete exomes of three Neandertals.<\/strong><br \/>\nCastellano S, Parra G, S\u00e1nchez-Quinto FA, Racimo F, <em>22 authors<\/em>, Meyer M, Kelso J, Andr\u00e9s AM, P\u00e4\u00e4bo S.<br \/>\n<em>Proc Natl Acad Sci USA<\/em>, 111:6666-71 (2014).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Advantageous diversity maintained by balancing selection in humans.<\/strong><br \/>\nKey FM, Teixeira JC, de Filippo C, Andr\u00e9s AM.<br \/>\n<em>Curr Opin Genet Dev<\/em>. 29:45-51 (2014).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Sequence diversity of <em>Pan troglodytes <\/em>subspecies and the impact of <em>WFDC6 <\/em>selective constraints in reproductive immunity.<\/strong><br \/>\nFerreira Z, Hurle B, Andr\u00e9s AM, Kretzschmar W, Mullikin J, Cherukuri P, Cruz P, Gonder MK, Stone A, Tishkoff S, Swanson W, NISC Comparative Sequencing Program, Green E, Clark AG, Seixas S.<br \/>\n<em>Genome Biology and Evolution<\/em>, 5:2512-2523 (2013).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Great ape genetic diversity and population history.<\/strong><br \/>\nPrado-Martinez J, Sudmant PH, Kidd JM, <em>66 authors,<\/em> Andr\u00e9s AM, Wall JD, Bustamante CD, Hammer MF, Eichler EE, Marques-Bonet T.<br \/>\n<em>Nature<\/em>, 499:471-5. (2013).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Reproduction and Immunity-Driven Natural Selection in the Human WFDC Locus.<\/strong><br \/>\nFerreira Z, Seixas S, Andr\u00e9s AM, Kretzschmar WW, Mullikin JC, Cherukuri PF, Cruz P, Swanson WJ, NISC Comparative Sequencing Program, Clark AG, Green ED and Hurle B.<br \/>\n<em>Molecular Biology and Evolution<\/em> 30: 938-950 (2013).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>A High-Coverage Genome Sequence from an Archaic Denisovan Individual.<\/strong><br \/>\nMeyer M, Kircher M, Gansauge MT, Li H, <em>24 authors<\/em>, Andr\u00e9s AM, Eichler EE, Slatkin M, Reich D, Kelso J, P\u00e4\u00e4bo S.<br \/>\n<em>Science <\/em>338:222-6 (2012). \u2013 Selected, Faculty of 1000 \u2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>The bonobo genome compared with the chimpanzee and human genomes.<\/strong><br \/>\nPr\u00fcfer K, Munch K, Hellmann I, Akagi K, <em>33 authors<\/em>, Schierup MH, Andr\u00e9s AM, Kelso J, P\u00e4\u00e4bo S.<br \/>\n<em>Nature,<\/em> 486:527-31 (2012).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Balancing selection maintains a form of <em>ERAP2<\/em> that undergoes nonsense-mediated decay and affects antigen presentation.<\/strong><br \/>\nAndr\u00e9s AM*, Dennis MY*, Kretzschmar WW, Cannons JL, Lee-Lin SQ, Hurle B; NISC Comparative Sequencing Program, Schwartzberg PL, Williamson SH, Bustamante CD, Nielsen R, Clark AG, Green ED.<em><br \/>\n<\/em><em>PLoS Genetics<\/em>, 6:e1001157 (2010).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Targets of balancing selection in the human genome.<\/strong><br \/>\nAndr\u00e9s AM, Hubisz MJ, Indap A, Degenhartl J, Boyco AR, Gutenkunst RN, White T, Green ED, Bustamante CD, Clark AG, and Nielsen R.<br \/>\n<em>Molecular Biology and Evolution<\/em>, 26:2755-64 (2009). \u2013 Selected, Faculty of 1000 \u2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Low exchangeability of selenocysteine, the 21<sup>st<\/sup> amino acid, in vertebrate proteins.<\/strong><br \/>\nCastellano S*, Andr\u00e9s AM*, Bosch E, Bayes M, Guig\u00f3 R, and Clark AG.<br \/>\n<em>Molecular Biology and Evolution,<\/em> 26:2031-40 (2009).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Darwinian and demographic forces affecting human protein coding genes.<\/strong><br \/>\nNielsen R, Hubisz MJ, Hellmann I, Torgerson D, Andr\u00e9s AM, Albrechtsen A, Gutenkunst R, Adams MD, Cargill M, Boyko A, Indap A, Bustamante CD, and Clark AG.<br \/>\n<em>Genome Research, <\/em>19:838-49 (2009). \u2013 Selected, Faculty of 1000 \u2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Heterogenetous rate of protein evolution in serotonin genes.<\/strong><br \/>\nAndr\u00e9s AM, de Hemptinne C, and Bertranpetit J.<br \/>\n<em>Molecular Biology and Evolution<\/em>, 24:2707-15 (2007).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Understanding the accuracy of statistical haplotype inference with sequence data of known phase.<\/strong><br \/>\nAndr\u00e9s AM, Clark AG, Shimmin L, Boerwinkle E, Sing CF, and Hixson JE.<br \/>\n<em>Genetic Epidemiology<\/em>, 31:659-71 (2007).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>The prion protein gene in humans revisited: lessons from a worldwide resequencing study.<\/strong><br \/>\nSoldevila M, Andr\u00e9s AM, Helgason A, Ram\u00edrez-Soriano A, Marqu\u00e9s-Bonet T, Sigurdadottir S, Calafell F, Navarro A, Stef\u00e1nsson K, and Bertranpetit J.<br \/>\n<em>Genome Research<\/em> 16:231-9 (2006).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Positive selection in MAOA gene is human exclusive: determination of the putative amino acid change selected in the human lineage.<\/strong><br \/>\nAndr\u00e9s AM, Soldevila M, Navarro A, Kidd KK, Oliva B, and Bertranpetit J.<br \/>\n<em>Human Genetics<\/em> 115:377-86 (2004).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Comparative genetics of functional trinucleotide tandem repeats in humans and apes.<\/strong><br \/>\nAndr\u00e9s AM, Soldevila M, Lao O, Volpini V, Saitou N, Jacobs HT, Hayasaka I, Calafell F, and Bertranpetit J.<br \/>\n<em>Journal of Molecular Evolution<\/em> 59:329-39 (2004).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Variation in the prion gene in chimpanzees and its implication for prion diseases.<\/strong><br \/>\nSoldevila M, Andr\u00e9s AM, Blancher A, Calafell F, Ordo\u00f1nez M, Pumarola M, Oliva B, Aramburu J, and Bertranpetit J.<br \/>\n<em>Neuroscience Letters<\/em> 355:157-16 (2004).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>A prevalent POLG CAG microsatellite length allele in humans and African great apes.<\/strong><br \/>\nRovio AT, Abel J, Ahola AL, Andr\u00e9s AM, <em>29 aditional authors,<\/em> Jacobs HT.<br \/>\n<em>Mammalian Genome<\/em> 15:492-502 (2004).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Comparative analysis of Alu insertion sequences in the APP 5\u2019flanking region in humans and other primates.<\/strong><br \/>\nClarim\u00f3n J, Andr\u00e9s AM, Bertranpetit J, and Comas D.<br \/>\n<em>Journal of Molecular Evolution<\/em> 58:722-731 (2004).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Prion Susceptibility and Protective Alleles Exhibit Marked Geographic Differences.<\/strong><br \/>\n<strong>Soldevila M,<\/strong> Calafell F, Andr\u00e9s AM, Yague J, Helgason A, Stef\u00e1nsson K, and Bertranpetit J.<br \/>\n<em>Human Mutation<\/em> 22:104-5 (2003).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Spatial patterns of cystic fibrosis mutation spectra in European populations.<\/strong><br \/>\nLao O, Andr\u00e9s AM, Mateu E, Bertranpetit J and Calafell F.<br \/>\n<em>European Journal of Human Genetics<\/em> 11:385-94 (2003).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Dynamics of CAG repeat loci revealed by the analysis of their variability.<\/strong><br \/>\nAndr\u00e9s AM, Lao O, Soldevila M, Calafell F, and Bertranpetit J.<br \/>\n<em>Human Mutation<\/em> 21:61-70 (2003).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Understanding the dynamics of Spinocerebellar Ataxia 8 (SCA8) locus through a comparative genetic approach in humans and apes.<\/strong><br \/>\nAndr\u00e9s AM, Soldevila M, Saitou N, Volpini V, Calafell F, and Bertranpetit J.<br \/>\n<em>Neuroscience Letters<\/em> 336:143-46 (2003).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>PKLR &#8211; GBA region shows almost complete linkage disequilibrium over 70 kb in a set of worldside populations.<\/strong><br \/>\nMateu E, P\u00e9rez-Lezaun A, Mart\u00ednez-Arias R, Andr\u00e9s A, Valles M, Bertranpetit J, and Calafell F.<br \/>\n<em>Human Genetics<\/em> 110:532-544 (2002).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Sequence variability of a human pseudogene.<\/strong><br \/>\nMart\u00ednez-Arias R, Calafell R, Mateu E, Comas D, Andr\u00e9s A, and Bertranpetit J.<br \/>\n<em>Genome Research<\/em> 11:1071-1085 (2002).<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Preprints Climate associated natural selection in the human mitochondrial genome. Grover-Thomas F, van Dorp L, Balloux F, Andr\u00e9s AM, Camus F. BioRxiv 2025. &nbsp; Papers Sudan\u2019s complex genetic admixture history drives adaptation to malaria in Sudanese Copts. Vil\u00e0-Valls L,\u00a0Garcia-Calleja J, Prado-Mart\u00ednez J, Bosch E, \u00a0Andr\u00e9s AM, Netea MG, Comas D, \u00a0Hassan HY. PNAS\u00a02026. 123 (3) <a class=\"more-link\" href=\"https:\/\/wp.cs.ucl.ac.uk\/evol-genome\/publications\/\">Continue reading <i class=\"fa fa-chevron-right\"><\/i><\/a><\/p>\n","protected":false},"author":118,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/wp.cs.ucl.ac.uk\/evol-genome\/wp-json\/wp\/v2\/pages\/22"}],"collection":[{"href":"https:\/\/wp.cs.ucl.ac.uk\/evol-genome\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wp.cs.ucl.ac.uk\/evol-genome\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wp.cs.ucl.ac.uk\/evol-genome\/wp-json\/wp\/v2\/users\/118"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.cs.ucl.ac.uk\/evol-genome\/wp-json\/wp\/v2\/comments?post=22"}],"version-history":[{"count":58,"href":"https:\/\/wp.cs.ucl.ac.uk\/evol-genome\/wp-json\/wp\/v2\/pages\/22\/revisions"}],"predecessor-version":[{"id":590,"href":"https:\/\/wp.cs.ucl.ac.uk\/evol-genome\/wp-json\/wp\/v2\/pages\/22\/revisions\/590"}],"wp:attachment":[{"href":"https:\/\/wp.cs.ucl.ac.uk\/evol-genome\/wp-json\/wp\/v2\/media?parent=22"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}